Thursday, May 25, 2023

IVG Reproduction Scientists are using a new method known as in vitro gametogenesis, or IVG, that could revolutionize the way babies are made -- This biotech could one day make human eggs from scratch

 

IVG will make possible a novel form of solo reproduction, which relies on the process of meiosis rather than mitosis. Meiosis involves a shuffling of the genetic material in each cell, producing genetically distinct gametes. 

Five things to know about IVG – a new way to have babies by turning any cell in our bodies into sperm or egg cells

Already trialled in mice, IVG or in vitro gametogenesis is the next frontier in reproductive medicine, allowing infertile people, same-sex couples, groups of more than two, or individuals, to become parents

Jeanette Wang
Jeanette Wang

A 3D illustration of a sperm about to inseminate an egg cell. In future, couples who lack either or both may be able to have children through a technique called IVG
A 3D illustration of a sperm about to inseminate an egg cell. In future, couples who lack either or both may be able to have children through a technique called IVG

Sperm from a man’s testes and an egg from a woman’s ovaries must come together for fertilisation to eventually produce offspring – it’s basic biology, isn’t it? Well, perhaps not in the future. A new experimental lab technology rapidly advancing in mouse studies suggests that some day, embryos could be created by reprogramming any type of adult cell to become a sperm or egg cell.

Known as in vitro gametogenesis (IVG), the technique would allow not only the medically infertile to have wholly biological children – that is, not involving any donors – but also same-sex couples, groups of more than two people, and even a single individual. IVG could also make prenatal selection a much more refined and comprehensive process than it is today, allowing for the selection of embryos that result in “perfect” children.."

Creating eggs and sperm from stem cells: the next big thing in assisted reproduction?

By I. Glenn Cohen and Alex PearlmanJune 5, 2019

Reprints
Mouse pups from same-sex parents
The parents of these mouse pups were a same-sex couple. A new assisted-reproduction process could someday make that possible in humans.LEYUN WANG

Until recently, the only way to make eggs or sperm was the old-fashioned way: in the ovaries and testes. In the not-too-distant future, it may be possible to use cells from almost any part of the body to create these germ cells, also known as gametes.

This process, called in vitro gametogenesis (IVG), raises the possibility that babies could be made using muscle or liver or blood cells. While not yet ready for prospective human parents — so far it has only been accomplished successfully in mice — it raises major ethical and legal questions that we should start thinking and talking about now.

IVG works like this: Cells from almost any tissue or organ are reverse engineered into becoming induced pluripotent stem cells. These cells, which can develop into any kind of human cell, are then nudged to become egg or sperm cells.

Why would anyone want to do this? Infertility due to cell failure or cancer treatment could cease to be the emotionally shattering issue it is for many families and individuals. It could also be a solution for women who experience premature menopause..."

READ MORE > STAT News 2019

Related: Congress weighs dropping ban on altering the DNA of human embryos used for pregnancies

REFERENCE TODAY MAY 25, 2023 

Ukraine's Delayed Offensive, IVG Reproduction, Preparing for Debt Default

Ukraine has been preparing for months to launch a counteroffensive against Russia's invasion, but the high stakes operation has seen many delays. Scientists are using a new method known as in vitro gametogenesis, or IVG, that could revolutionize the way babies are made. And if the government defaults on its debt, people will have a harder time borrowing money.

In Vitro Gametogenesis IVG - Embryology Way to Design a Baby



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THE SEVERITY OF MENTAL PENDULUM SWINGS: An overwhelming dichotomy of emotions...The ludicrosity of life can make you crazy

Kesha Channels Her Emotions into ‘Only Love Can Save Us Now’ Live Performance

The hard-hitting song comes off the singer's recent LP, Gag Order
Kesha
Kesha. KESHA/VEVO

KESHA SHOWCASED HER recent song “Only Love Can Save Us Now” in a video performance for Vevo. Accompanied by a pair of musicians, Kesha performed the fast-talking track, which appears on her new album Gag Order, in a rectangular room with flickering lights, giving it a punk flair.

“I have had an overwhelming dichotomy of emotions, oscillating between pain and love. Chaos and love. Fear and love,” Kesha said in a statement. “I wanted my song ‘Only Love Can Save Us Now’ to sonically, lyrically, and emotionally reflect the severity of my mental pendulum swings. The world is so overwhelming sometimes. It requires a moment of surrender. The ludicrosity of life can make you crazy. If anything, if anything, can save us, I believe only love can. This song is a desperate and angry prayer. A call to the light when all feels lost.”

Kesha recorded Gag Order, her fifth studio LP, with producer Rick Rubin. The album marks her first since 2020’s High Road.

“I feel like I’m giving birth to the most intimate thing I’ve ever created,” the singer told Rolling Stone of the album, released earlier this month. I really dug into some of my uglier emotions and sides of myself that are less fun. It’s scary being vulnerable. The fact that I have compiled an entire record of these emotions, of anger, of insecurity, of anxiety, of grief, of pain, of regret, all of that is so nerve-racking — but it’s also so healing.”

On the album, Kesha vaguely addresses her ongoing legal situation with Dr. Luke. (Kesha has accused the producer, real name Lukasz Gottwald, of sexual, physical, and emotional abuse; he has denied the allegations, and his defamation suit against Kesha is set to go to trial this summer.) While she’s not allowed to discuss the issue directly, she told Rolling Stone that the LP’s title sums up how she feels..."

LINK Rolling Stone


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RETURN OF THE AMERICAN DOMINO THEORY: Endle$$$$$$$$$$ War...because Americans themselves are not in harm’s way

Goldberg: [Zelenskiy] has this domino theory that goes like this: If the West allows Ukraine to fall, or to come under even partial permanent control of Russia, Russia does not stop. Russia goes into Moldova.

Zelensky: If they will occupy us, they will be on the borders of Moldova, and they will occupy Moldova. When they will occupy Moldova through Belarus, they will occupy Baltic countries, which are members of NATO. Of course they are brave people and they will fight—but they are small. And they don’t have nuclear weapon. And when they will occupy NATO countries, the question is, will you send all your soldiers with weapons, all your pilots, all your ships? Will you send tanks and armored vehicles with your young people? Will you do? Because if you will not do it, you will have no NATO.

The War Is Not Here to Entertain You

The war in Ukraine is reaching a critical moment. Will it recapture the world’s flagging attention?

By Hanna Rosin, A.C. Valdez, and Claudine Ebeid
Two members of the Ukrainian 28th Mechanized Brigade ride in an armored vehicle towards hostile Russian forces. The one on the left is smoking a cigarette, the one on the right is scowling, and to their side is a blue and yellow flag.
Members of the Ukrainian 28th Mechanized Brigade ride in a BMP armored vehicle during a mission to fire a SPG-9 recoilless gun at a Russian target in the direction of Bakhmut in eastern Ukraine, May 8, 2023 (Tyler Hicks / NYT / Redux)


"There might be some Americans who, a year-plus into the Ukraine war, might be growing numb to it. Some of those Americans might include me, the new host of Radio Atlantic. In my first episode, I confess this to Atlantic editor in chief Jeffrey Goldberg and staff writer Anne Applebaum, who have just returned from a trip to Ukraine. We talk about their interview with Ukrainian President Volodymyr Zelensky, why continued American support is necessary, and why my flagging attention doesn’t matter.

Applebaum, who has covered the war from start, clarifies the confusing but potentially critical recent developments. Anti-Putin forces conducted a raid inside Russia. And after months of a bloody battle, Bakhmut, Ukraine, is for the moment under Russian control, while Ukrainian forces push at the flanks of the city. We analyze whether this is the start of the much-discussed spring offensive, and where the war might be headed.

The following is a transcript of the episode:

Hanna Rosin: I’m Hanna Rosin, and this is Radio Atlantic. My colleagues, Atlantic staff, writer Anne Applebaum and editor-in-Chief Jeffrey Goldberg just got back from Ukraine. They returned with a sense that something big was going to happen, and now it seems to be starting. This week, it looks like Russia has taken Bakhmut, a city where the fighting has been vicious and sustained, although the Ukrainians haven't surrendered yet. At the same time, there’s been a raid inside Russia by anti-Putin forces. Now, I have to admit: I’ve become a little numb to this war. I’m just not following it as closely as I used to. So, I got Anne in the studio to bring this moment into focus.

Rosin: All right, I think maybe let’s start with the attacks behind the Russian border. What do we know about what happened?

Anne Applebaum: We know that a small group of people describing themselves as “Free Russian” forces crossed the border from Ukraine into Russia near a city called Belgorod and occupied several villages. They seemed to have frightened people enough to cause a major evacuation.

They stayed for some period of time, so it wasn’t just that they crossed over for an hour and came back. And they described themselves as wanting to use this as a way to provoke Putin or unseat Putin. . .

[    ] READ BETWEEN THE LINES > The Atlantic

Goldberg: You know what? We’ve been in Korea since 1950. The thing that allows us to stay in Korea that did not allow us to stay in Iraq or Afghanistan is that American soldiers aren’t dying. If the bullied, if the oppressed, if the invaded can defend themselves—if we provide them with some guns—isn’t that a better formula? And, by the way, it’s also a formula that Americans can live with, because Americans themselves are not in harm’s way.

Rosin: This is actually the perfect and correct kind of engagement for an age of limited attention span. Who cares if people don’t care? Who cares if people aren’t reading? Like, my question is not that relevant a question , because we’ve actually designed a form of engagement that’s effective, necessary…

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8 MONTHS AGO STREAMED LIVE ON OCT 27, 2022 >> Germany Heads For Recession: Survey | Germany Economic Crisis 2022 News Live 2022

 
 

Mohamed A. El-Erian
@elerianm
The just-released revisions to Germany’s growth data point to a 0.3% contraction in GDP in the first quarter of this year (the initial estimate was 0%). As this follows the 0.5% GDP fall in the prior quarter, Germany is now officially in a recession. #growth #economy #Germany… Show more
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