01 July 2022

TESTING NEUTRAL MUTATIONS IN YEAST TO TRACK PROTEIN EVOLUTION

So, does that mean it's time to throw out our idea that mutations in a gene that don't alter its protein sequence are neutral? And with it, all the tools we use to study protein evolution that are based on this assumption?

Worse than it looked —

Mutations thought to be harmless turn out to cause problems

Mutations in genes that don't alter proteins can still alter survival in yeast.

<div class=__reading__mode__extracted__imagecaption>Enlarge/ The genetic code. Note that a lot of the amino acids (the outer layer, in grey) are encoded by several sets of three-base codes that share the first two letters.Wikipedia

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