A new nasal spray reversed signs of brain aging.

From Quarks to Quasars 

 Researchers at Texas A&M University tested an experimental treatment designed to reduce the chronic inflammation that can build up in the brain with age.The treatment contains tiny particles released by lab-grown human neural stem cells. These particles carry molecules that help regulate activity inside cells, including signals involved in inflammation.

Delivered through the nose, the particles reached the brain. Treated mice showed reduced inflammation in the hippocampus, a region important for learning and memory, along with changes in genes involved in cellular energy production after just two doses.

Those biological changes were accompanied by better performance on tests involving objects and changes in the animals’ surroundings. Benefits were seen in both male and female mice.

The findings suggest that some processes linked to age-related memory decline may be treatable. But this was an animal study, not evidence that a nasal spray can reverse brain aging or treat dementia in people.

Further research is needed to establish whether the approach is safe and effective in humans. The study was published in the Journal of Extracellular Vesicles.

Read the study:

"Intranasal Human NSC‐Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS‐STING Signalling, in Aged Hippocampus." Journal of Extracellular Vesicles

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